PUS7L

Across TCGA cell cohorts, PUS7L mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PUS7L-associated genes across cancer lineages are PRAMEF27, TGM7, and PGK2. Each is linked with PUS7L in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS7L-to-partner and partner-to-PUS7L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF27 grouped by PUS7L-low versus PUS7L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS7L→partner) and Y-score (partner→PUS7L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF27 →	+0.003	+4.022	<.001	.006	3	2
SOFT_TISSUE	TGM7 →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2T12 →	+0.586	+5.977	<.001	.001	3	1
SOFT_TISSUE	TAS2R60 →	+0.021	+4.930	.001	.008	3	1
SOFT_TISSUE	SSX7 →	+0.019	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PRAMEF27 by PUS7L expression — LARGE_INTESTINE

Explore this box plot interactively →