PUS3

Across TCGA patient cohorts, PUS3 mutation is significantly associated with the RNA expression of many other genes, with 2,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS3-associated genes across cancer lineages are RNA5SP226, LIN7C, and HSD17B12. Each is linked with PUS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS3-to-partner and partner-to-PUS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP226 grouped by PUS3-low versus PUS3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS3→partner) and Y-score (partner→PUS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP226 →	+0.360	+4.719	<.001	.003	3	2
UCEC	LIN7C →	+0.581	+3.743	.002	<.001	3	1
UCEC	HSD17B12 →	+0.498	+3.343	.005	.005	3	1
UCEC	APIP →	+0.467	+3.212	.005	<.001	3	1
UCEC	DGKZ →	+0.336	+3.470	.008	.002	3	1
UCEC	SSRP1 →	+0.539	+3.639	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,831 associations by consensus.

RNA5SP226 by PUS3 expression — BLCA

Explore this box plot interactively →