PUS3

Across TCGA pan-cancer cohorts, PUS3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PUS3 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PUS3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PUS3 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

ACC, KIRP, and LGG are the cancer types where PUS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.241	0.692	<.001	82	view →
KIRP	DFS	Tertile	All	0.778	0.944	.002	58	view →
LGG	DFS	Median	All	0.882	0.764	.002	24	view →
HNSC	DFS	Median	All	0.246	0.398	.001	23	view →
SCLC	OS	Median	All	0.466	0.688	.005	19	view →
KIRC	DFS	Median	II,III,IV	0.777	0.538	.002	18	view →
DLBC	DFS	Quartile	II,III,IV	0.429	0.855	.028	18	view →
TGCT	DFS	Median	All	0.705	0.883	.005	16	view →
KICH	OS	Median	II,III,IV	0.651	0.959	.006	15	view →
LUAD	DFS	Quartile	IV	1.000	0.376	.040	12	view →
UVM	DFS	Median	III,IV	0.274	0.680	.009	12	view →
BLCA	OS	Median	IV	0.180	0.378	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PUS3–ACC (DFS)

Open the ACC breakdown →