PUS3

Across TCGA patient cohorts, PUS3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS3-associated genes across cancer lineages are Ku80, MEK1, and N-Ras. Each is linked with PUS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS3-to-partner and partner-to-PUS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by PUS3-low versus PUS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS3→partner) and Y-score (partner→PUS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.207	+1.713	.039	.027	3	1
UCEC	MEK1 →	+0.336	+2.999	.030	.035	3	1
UCEC	N-Ras →	+0.140	+2.189	.005	.034	3	1
UCEC	PCNA →	+0.195	+2.000	.033	.030	3	1
UCEC	PDCD4 →	-0.550	-2.312	.005	.034	3	1
UCEC	Rb_pS807_S811 →	-0.495	-3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by PUS3 expression — UCEC

Explore this box plot interactively →