PUS3

Across TCGA cell cohorts, PUS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,071 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PUS3-associated GO terms across cancer lineages are tRNA pseudouridine synthesis, mRNA pseudouridine synthesis, and mRNA modification. Each is linked with PUS3 in more than 17 cancer types. Because this analysis shows association rather than direction, both PUS3-to-partner and partner-to-PUS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA pseudouridine synthesis grouped by PUS3-low versus PUS3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS3→partner) and Y-score (partner→PUS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	tRNA pseudouridine synthesis →	+0.134	+1.024	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	mRNA pseudouridine synthesis →	+0.108	+1.047	.002	<.001	3	15
BONE	mRNA modification →	+0.088	+0.993	.006	.001	3	12
LUNG_NSCLC_LUAD	Positive regulation of protein acetylation →	+0.081	+0.523	<.001	<.001	3	12
CNS	tRNA processing →	+0.049	+0.816	<.001	<.001	3	10
BLOOD_Lymphoma	Ribosomal large subunit export from nucleus →	+0.113	+0.798	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,071 associations by consensus.

tRNA pseudouridine synthesis by PUS3 expression — BREAST

Explore this box plot interactively →