PUS3

Across TCGA cell cohorts, PUS3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PUS3-associated genes across cancer lineages are PRAMEF20, SIGLEC8, and SCGB3A2. Each is linked with PUS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS3-to-partner and partner-to-PUS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by PUS3-low versus PUS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS3→partner) and Y-score (partner→PUS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	2
LARGE_INTESTINE	SIGLEC8 →	+0.010	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.256	+3.510	.008	.003	3	1
LARGE_INTESTINE	NPY2R →	+0.004	+3.632	<.001	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.195	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRAMEF20 by PUS3 expression — LARGE_INTESTINE

Explore this box plot interactively →