PUS10

Across TCGA cell cohorts, PUS10 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PUS10-associated genes across cancer lineages are MDGA2, FCN2, and TLX3. Each is linked with PUS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS10-to-partner and partner-to-PUS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDGA2 grouped by PUS10-low versus PUS10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS10→partner) and Y-score (partner→PUS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDGA2 →	+0.207	+4.176	<.001	.001	3	1
LARGE_INTESTINE	FCN2 →	+0.033	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	TLX3 →	+0.497	+3.845	<.001	.003	3	1
LARGE_INTESTINE	OR2C1 →	+0.101	+3.725	.002	.008	3	1
LARGE_INTESTINE	MAGEB10 →	+0.072	+3.345	<.001	.007	3	1
LARGE_INTESTINE	MAGEB1 →	+0.239	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MDGA2 by PUS10 expression — LARGE_INTESTINE

Explore this box plot interactively →