PUS1

Across TCGA pan-cancer cohorts, PUS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PUS1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PUS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PUS1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where PUS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.368	0.818	.001	46	view →
HNSC	OS	Tertile	All	0.760	0.925	.003	23	view →
LSCC	OS	Median	All	1.000	0.937	.012	21	view →
LUAD	DFS	Median	III,IV	0.738	0.230	.003	19	view →
PDAC	OS	Median	IV	0.425	0.810	.046	3	view →
GBM	DFS	Quartile	All	0.787	0.911	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PUS1–CCRCC (DFS)

Open the CCRCC breakdown →