PUS1

Across TCGA pan-cancer cohorts, PUS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PUS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PUS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PUS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where PUS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PUS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.690	<.001	12	view →
COAD	Female	All	+1.946	<.001	11	view →
HNSC	Male	III,IV	+1.280	<.001	11	view →
BLCA	Male	All	+1.021	<.001	11	view →
KIRP	Male	III,IV	+0.917	<.001	11	view →
STAD	All	III,IV	+1.468	<.001	9	view →
LIHC	Male	III,IV	+1.411	<.001	9	view →
LUAD	Female	III,IV	+1.132	<.001	9	view →
LUSC	Male	III,IV	+1.677	<.001	8	view →
UCEC	All	All	+0.854	<.001	6	view →
BRCA	All	All	+0.422	<.001	6	view →
CHOL	Male	All	+1.831	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PUS1–KIRC

Open the KIRC breakdown →