PUS1

Across TCGA patient cohorts, PUS1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Fibronectin. Each is linked with PUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS1-to-partner and partner-to-PUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PUS1-low versus PUS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS1→partner) and Y-score (partner→PUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.278	-2.115	.011	.019	3	1
UCEC	eIF4E →	+0.236	+3.013	.010	.018	3	1
UCEC	Fibronectin →	-0.338	-3.449	.019	.005	3	1
UCEC	JNK2 →	+0.207	+2.834	.017	.034	3	1
UCEC	MEK1 →	+0.437	+2.807	.006	.003	3	1
UCEC	Notch1 →	+0.150	+2.335	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by PUS1 expression — UCEC

Explore this box plot interactively →