PUS1

Across TCGA cell cohorts, PUS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,584 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PUS1-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Ribosomal large subunit biogenesis, and rRNA processing. Each is linked with PUS1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PUS1-to-partner and partner-to-PUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by PUS1-low versus PUS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS1→partner) and Y-score (partner→PUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of SSU-rRNA →	+0.129	+1.239	<.001	.002	3	18
LUNG_SCLC	Ribosomal large subunit biogenesis →	+0.120	+1.030	<.001	<.001	3	18
LIVER	rRNA processing →	+0.132	+1.228	.003	.001	3	18
UPPER_AERODIGESTIVE_TRACT	Mitochondrial tRNA pseudouridine synthesis →	+0.171	+1.040	<.001	<.001	3	17
KIDNEY	Regulation of mitochondrial RNA catabolic process →	+0.116	+0.818	.005	.003	3	17
BONE	Pseudouridine synthesis →	+0.120	+1.185	<.001	.002	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,584 associations by consensus.

Maturation of SSU-rRNA by PUS1 expression — BONE

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