PUS1

Across TCGA cell cohorts, PUS1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PUS1-associated genes across cancer lineages are CRYBB1, NPVF, and GLYATL3. Each is linked with PUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS1-to-partner and partner-to-PUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by PUS1-low versus PUS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS1→partner) and Y-score (partner→PUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRYBB1 →	+0.662	+2.878	<.001	.009	3	2
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	CABS1 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR2T12 →	+0.035	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CRYBB1 by PUS1 expression — LARGE_INTESTINE

Explore this box plot interactively →