PUS1

Across TCGA cell cohorts, PUS1 mutation is significantly associated with the mutation status of many other genes, with 2,791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PUS1-associated genes across cancer lineages are SIN3B, PTPRG, and PIWIL3. Each is linked with PUS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PUS1-to-partner and partner-to-PUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIN3B grouped by PUS1-low versus PUS1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS1→partner) and Y-score (partner→PUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SIN3B →	+5.000	+5.000	.006	.006	1	3
KIDNEY	PTPRG →	+5.000	+5.000	.006	.006	1	3
LUNG_NSCLC_LUAD	PIWIL3 →	+4.772	+5.339	.004	.004	1	3
LARGE_INTESTINE	SLX4 →	+2.099	+4.064	.001	.001	1	3
LARGE_INTESTINE	PKHD1L1 →	+1.478	+3.408	.007	.007	1	3
LUNG_NSCLC_LUAD	MECP2 →	+4.187	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,791 associations by consensus.

SIN3B by PUS1 expression — KIDNEY

Explore this box plot interactively →