Across TCGA patient cohorts, PURA RNA expression is significantly associated with the protein abundance of many other proteins, with 18,801 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PURA-associated proteins across cancer lineages are RPL4, PSME4, and DDX21_S71. Each is linked with PURA in more than 5 cancer types. Because this analysis shows association rather than direction, both PURA-to-partner and partner-to-PURA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PURA→partner) and Y-score (partner→PURA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL4 →	-0.341	-0.410	.001	.001	3	6
BRCA	PSME4 →	-0.354	-0.653	<.001	.001	3	6
BRCA	DDX21_S71 →	-1.224	-0.585	<.001	<.001	3	6
BRCA	SORBS1 →	+0.575	+0.683	<.001	<.001	3	6
CCRCC	SORBS3 →	+0.287	+0.386	.003	<.001	3	6
LUAD	CHEK2 →	-0.543	-0.571	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,801 associations by consensus.

Exploration

PURA survival (RNA) · tumor vs normal (RNA) · all PURA data types