Across TCGA patient cohorts, PURA protein abundance is significantly associated with the RNA expression of many other genes, with 19,330 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PURA-associated genes across cancer lineages are CBX7, CDKN3, and TTK. Each is linked with PURA in more than 9 cancer types. Because this analysis shows association rather than direction, both PURA-to-partner and partner-to-PURA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURA→partner) and Y-score (partner→PURA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CBX7 →	+0.751	+0.394	<.001	<.001	3	10
LUAD	CDKN3 →	-1.189	-0.355	<.001	<.001	3	10
LSCC	TTK →	-1.248	-0.314	<.001	<.001	3	10
LUAD	CENPA →	-1.330	-0.380	<.001	<.001	3	10
LUAD	DLGAP5 →	-1.325	-0.338	<.001	<.001	3	10
BRCA	CDCA8 →	-1.144	-0.456	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,330 associations by consensus.

Exploration

PURA survival (RNA) · tumor vs normal (RNA) · all PURA data types