Across TCGA patient cohorts, PURA protein abundance is significantly associated with the protein abundance of many other proteins, with 34,537 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PURA-associated proteins across cancer lineages are PSME4, PTPN2_S304, and NCAPD2. Each is linked with PURA in more than 9 cancer types. Because this analysis shows association rather than direction, both PURA-to-partner and partner-to-PURA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PURA→partner) and Y-score (partner→PURA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PSME4 →	-0.488	-0.392	<.001	<.001	3	10
OV	PTPN2_S304 →	-0.823	-0.546	<.001	<.001	3	10
LUAD	NCAPD2 →	-0.821	-0.409	<.001	<.001	3	10
LUAD	NCL_S67 →	-1.051	-0.309	<.001	<.001	3	10
LUAD	SMC2 →	-0.676	-0.384	<.001	<.001	3	10
LUAD	TRIP13 →	-1.008	-0.366	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 34,537 associations by consensus.

Exploration

PURA survival (RNA) · tumor vs normal (RNA) · all PURA data types