Across TCGA patient cohorts, PURA mutation is significantly associated with the RNA expression of many other genes, with 785 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PURA-associated genes across cancer lineages are MIR4510, RPL23AP4, and HNRNPA1P19. Each is linked with PURA in more than 1 cancer types. Because this analysis shows association rather than direction, both PURA-to-partner and partner-to-PURA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURA→partner) and Y-score (partner→PURA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
CESC	RPL23AP4 →	+0.149	+4.193	<.001	.009	3	2
COAD	HNRNPA1P19 →	+0.274	+4.042	<.001	.005	3	2
BRCA	RN7SL722P →	+0.189	+8.471	<.001	.005	3	1
LIHC	UBE2FP2 →	+0.090	+5.174	.002	.001	3	1
LIHC	TBC1D3P5 →	+0.010	+4.607	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 785 associations by consensus.

Exploration

PURA survival (RNA) · tumor vs normal (RNA) · all PURA data types