Across TCGA patient cohorts, PURA mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PURA-associated genes across cancer lineages are Cyclin-E2, JNK_pT183_Y185, and STAT3_pY705. Each is linked with PURA in more than 1 cancer types. Because this analysis shows association rather than direction, both PURA-to-partner and partner-to-PURA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURA→partner) and Y-score (partner→PURA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.270	+2.817	.005	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.222	-2.986	.022	.037	3	1
UCEC	STAT3_pY705 →	-0.687	-2.999	<.001	.035	3	1
UCEC	Tuberin →	+0.470	+3.009	.002	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.804	-2.986	.001	.037	2	1
UCEC	p62 Lck ligand →	+0.544	+2.817	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

PURA survival (RNA) · tumor vs normal (RNA) · all PURA data types