PUM3

Across TCGA patient cohorts, PUM3 mutation is significantly associated with the RNA expression of many other genes, with 3,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUM3-associated genes across cancer lineages are HNRNPCL3, USP9YP5, and BPNT2P. Each is linked with PUM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUM3-to-partner and partner-to-PUM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPCL3 grouped by PUM3-low versus PUM3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM3→partner) and Y-score (partner→PUM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HNRNPCL3 →	+0.136	+3.707	<.001	.009	3	2
READ	USP9YP5 →	+0.163	+7.276	<.001	<.001	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
UCEC	LMF2 →	+0.477	+2.736	.001	<.001	3	2
UCEC	ZC3H14 →	+0.399	+1.869	.001	.005	3	2
UCEC	USP14 →	+0.570	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,226 associations by consensus.

HNRNPCL3 by PUM3 expression — BRCA

Explore this box plot interactively →