PUM2

Across TCGA patient cohorts, PUM2 mutation is significantly associated with the RNA expression of many other genes, with 2,861 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUM2-associated genes across cancer lineages are LINC00430, SNORD114-24, and IGHD6-19. Each is linked with PUM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUM2-to-partner and partner-to-PUM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00430 grouped by PUM2-low versus PUM2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM2→partner) and Y-score (partner→PUM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	LINC00430 →	+0.054	+5.902	<.001	.001	3	2
CESC	SNORD114-24 →	+0.318	+5.164	<.001	.002	3	2
LIHC	IGHD6-19 →	+1.107	+4.544	<.001	.009	3	2
LIHC	ARF4P4 →	+0.076	+4.544	<.001	.009	3	2
CESC	IGLC4 →	+0.213	+4.488	.008	<.001	3	2
COAD	OR52P2P →	+0.081	+3.187	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,861 associations by consensus.

LINC00430 by PUM2 expression — LIHC

Explore this box plot interactively →