PUM2

Across TCGA pan-cancer cohorts, PUM2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated PUM2 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PUM2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PUM2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

KIRC, ACC, and LUSC are the cancer types where PUM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.765	0.597	<.001	92	view →
ACC	DFS	Median	All	0.283	0.618	<.001	71	view →
LUSC	DFS	Tertile	All	0.820	0.704	.001	53	view →
HNSC	DFS	Quartile	IV	0.773	0.551	.001	45	view →
LIHC	OS	Median	All	0.714	0.837	<.001	43	view →
THYM	DFS	Quartile	All	0.852	0.587	<.001	33	view →
KIRP	DFS	Median	III,IV	0.143	0.620	.006	32	view →
UCS	OS	Tertile	II,III,IV	0.684	0.203	.010	28	view →
UVM	DFS	Quartile	III,IV	0.106	1.000	.010	27	view →
READ	OS	Median	III,IV	0.863	0.648	.004	23	view →
GBM	DFS	Tertile	All	0.506	0.216	<.001	18	view →
OV	DFS	Median	III,IV	0.180	0.132	.015	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

PUM2–KIRC (OS)

Open the KIRC breakdown →