PUM2

Across TCGA patient cohorts, PUM2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUM2-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and N-Ras. Each is linked with PUM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUM2-to-partner and partner-to-PUM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PUM2-low versus PUM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM2→partner) and Y-score (partner→PUM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.251	+2.321	.014	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.180	-1.723	<.001	<.001	3	2
UCEC	N-Ras →	-0.078	-1.156	.023	.017	3	2
UCEC	4E-BP1 →	+0.305	+4.087	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.101	-2.074	.018	.004	3	2
UCEC	14-3-3_beta →	-0.078	-2.143	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by PUM2 expression — UCEC

Explore this box plot interactively →