PUM2

Across TCGA cell cohorts, PUM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,446 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PUM2-associated GO terms across cancer lineages are Positive regulation of organelle assembly, Heterochromatin organization, and Negative regulation of chromosome condensation. Each is linked with PUM2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PUM2-to-partner and partner-to-PUM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of organelle assembly grouped by PUM2-low versus PUM2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM2→partner) and Y-score (partner→PUM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.078	+0.764	<.001	<.001	3	17
SOFT_TISSUE	Heterochromatin organization →	+0.058	+0.491	<.001	<.001	3	17
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.161	+0.652	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.068	+0.539	<.001	<.001	3	16
STOMACH	Epigenetic regulation of gene expression →	+0.065	+0.670	.008	.004	3	16
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.071	+0.549	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,446 associations by consensus.

Positive regulation of organelle assembly by PUM2 expression — BLOOD_Myeloma

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