PUM2

Across TCGA cell cohorts, PUM2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PUM2-associated genes across cancer lineages are KRTAP10-10, MAGEB4, and GGTLC1. Each is linked with PUM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUM2-to-partner and partner-to-PUM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-10 grouped by PUM2-low versus PUM2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM2→partner) and Y-score (partner→PUM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRTAP10-10 →	+0.036	+5.169	<.001	.005	3	2
LUNG_NSCLC_LUAD	MAGEB4 →	+0.006	+5.662	<.001	.002	3	2
BONE	GGTLC1 →	+0.049	+5.169	<.001	.004	3	1
BONE	ASCL4 →	+0.016	+5.169	<.001	.004	3	1
BONE	OR8A1 →	+0.090	+5.169	<.001	.004	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

KRTAP10-10 by PUM2 expression — BREAST

Explore this box plot interactively →