PUDP

Across TCGA patient cohorts, PUDP mutation is significantly associated with the RNA expression of many other genes, with 1,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUDP-associated genes across cancer lineages are OR4K17, RNA5SP358, and EIF4EBP2P3. Each is linked with PUDP in more than 1 cancer types. Because this analysis shows association rather than direction, both PUDP-to-partner and partner-to-PUDP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K17 grouped by PUDP-low versus PUDP-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUDP→partner) and Y-score (partner→PUDP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR4K17 →	+0.020	+5.523	.004	.001	3	2
LUAD	RNA5SP358 →	+0.222	+4.399	<.001	.008	3	2
LUAD	EIF4EBP2P3 →	+0.076	+4.303	.004	.009	3	2
LUAD	H3P15 →	+0.053	+4.502	.008	.007	3	2
UCEC	SYPL1P1 →	+0.100	+2.479	<.001	.001	3	2
CESC	FARSBP1 →	+0.033	+4.669	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,832 associations by consensus.

OR4K17 by PUDP expression — LUAD

Explore this box plot interactively →