PTX3

Across TCGA patient cohorts, PTX3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,739 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTX3-associated genes across cancer lineages are FPR2, CXCL8, and ADGRG3. Each is linked with PTX3 in more than 7 cancer types. Because this analysis shows association rather than direction, both PTX3-to-partner and partner-to-PTX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTX3 versus FPR2 in COAD, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX3→partner) and Y-score (partner→PTX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FPR2 →	+1.332	+0.679	<.001	<.001	3	8
GBM	CXCL8 →	+2.419	+1.087	<.001	<.001	3	8
LSCC	ADGRG3 →	+0.992	+0.831	<.001	<.001	3	8
GBM	TREML4 →	+0.659	+1.105	<.001	<.001	3	7
LSCC	ADGRE3 →	+0.702	+0.708	<.001	<.001	3	7
COAD	BCL2A1 →	+1.408	+0.597	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,739 associations by consensus.

PTX3 vs FPR2 — COAD

Explore this scatter interactively →