PTX3

Across TCGA patient cohorts, PTX3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTX3-associated genes across cancer lineages are MEK1, Src_pY527, and ERK2. Each is linked with PTX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTX3-to-partner and partner-to-PTX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PTX3-low versus PTX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX3→partner) and Y-score (partner→PTX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.375	+2.459	.034	.020	3	2
UCEC	Src_pY527 →	-0.504	-2.999	.015	.035	3	2
UCEC	ERK2 →	+0.238	+2.459	.010	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.186	-3.160	.002	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.540	+2.331	.027	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-2.446	.007	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MEK1 by PTX3 expression — UCEC

Explore this box plot interactively →