PTX3

Across TCGA cell cohorts, PTX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,517 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTX3-associated GO terms across cancer lineages are Regulation of plasminogen activation, Negative regulation of plasminogen activation, and Positive regulation of extracellular matrix organization. Each is linked with PTX3 in more than 12 cancer types. Because this analysis shows association rather than direction, both PTX3-to-partner and partner-to-PTX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasminogen activation grouped by PTX3-low versus PTX3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX3→partner) and Y-score (partner→PTX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of plasminogen activation →	+0.302	+2.560	.002	.001	3	13
BONE	Negative regulation of plasminogen activation →	+1.399	+2.771	<.001	<.001	3	13
SKIN	Positive regulation of extracellular matrix organization →	+0.157	+3.042	<.001	<.001	3	13
CNS	Regulation of protein K48-linked ubiquitination →	+0.115	+2.987	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Plasminogen activation →	+0.411	+2.903	<.001	<.001	3	12
CNS	Establishment of epithelial cell apical/basal polarity →	+0.171	+3.054	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,517 associations by consensus.

Regulation of plasminogen activation by PTX3 expression — LIVER

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