PTTG1IP

Across TCGA patient cohorts, PTTG1IP mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTTG1IP-associated genes across cancer lineages are RNA5SP321, MIR4324, and GCATP1. Each is linked with PTTG1IP in more than 1 cancer types. Because this analysis shows association rather than direction, both PTTG1IP-to-partner and partner-to-PTTG1IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP321 grouped by PTTG1IP-low versus PTTG1IP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTTG1IP→partner) and Y-score (partner→PTTG1IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP321 →	+0.320	+6.289	<.001	.001	3	1
UCEC	MIR4324 →	+0.977	+2.883	.002	.004	3	1
UCEC	GCATP1 →	+0.421	+3.502	.001	.002	3	1
UCEC	LINC01607 →	-0.700	-3.448	.005	.005	3	1
UCEC	TRAJ37 →	+1.012	+2.981	<.001	<.001	3	1
HNSC	MIR132 →	+0.508	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

RNA5SP321 by PTTG1IP expression — BLCA

Explore this box plot interactively →