PTTG1IP

Across TCGA pan-cancer cohorts, PTTG1IP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PTTG1IP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTTG1IP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTTG1IP is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where PTTG1IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTTG1IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.820	<.001	12	view →
KIRC	Female	All	+0.680	<.001	11	view →
KICH	Female	II,III,IV	−1.342	<.001	8	view →
LIHC	Female	All	+0.709	<.001	6	view →
BRCA	All	III,IV	+0.602	<.001	6	view →
COAD	Female	All	−0.678	<.001	5	view →
STAD	Male	II,III,IV	+0.584	.006	5	view →
LUAD	All	II,III,IV	+0.389	<.001	5	view →
LUSC	Male	All	−0.419	<.001	4	view →
CHOL	Male	All	+1.923	<.001	3	view →
UCEC	All	IV	−1.015	.011	2	view →
READ	All	All	−0.532	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PTTG1IP–HNSC

Open the HNSC breakdown →