PTTG1IP

Across TCGA patient cohorts, PTTG1IP mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTTG1IP-associated genes across cancer lineages are Rictor_pT1135, Caspase-7-cleavedD198, and eIF4E. Each is linked with PTTG1IP in more than 1 cancer types. Because this analysis shows association rather than direction, both PTTG1IP-to-partner and partner-to-PTTG1IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by PTTG1IP-low versus PTTG1IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTTG1IP→partner) and Y-score (partner→PTTG1IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.165	-3.000	.002	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.769	+2.827	.013	.035	3	1
UCEC	eIF4E →	+0.252	+3.321	.022	.010	2	1
UCEC	p70-S6K →	+0.266	+2.196	.008	.034	2	1
UCEC	p62 Lck ligand →	+0.603	+3.321	<.001	.010	1	1
UCEC	4E-BP1 →	+0.336	+3.321	.017	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Rictor_pT1135 by PTTG1IP expression — UCEC

Explore this box plot interactively →