PTTG1IP

Across TCGA cell cohorts, PTTG1IP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,520 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PTTG1IP-associated GO terms across cancer lineages are Regulation of proteolysis, Positive regulation of canonical NF-kappaB signal transduction, and Fusion of virus membrane with host plasma membrane. Each is linked with PTTG1IP in more than 13 cancer types. Because this analysis shows association rather than direction, both PTTG1IP-to-partner and partner-to-PTTG1IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteolysis grouped by PTTG1IP-low versus PTTG1IP-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTTG1IP→partner) and Y-score (partner→PTTG1IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of proteolysis →	+0.121	+1.481	.003	<.001	3	14
PANCREAS	Positive regulation of canonical NF-kappaB signal transduction →	+0.046	+1.012	<.001	<.001	3	14
BLOOD_Lymphoma	Fusion of virus membrane with host plasma membrane →	+1.065	+0.782	<.001	.003	3	14
BLOOD_Lymphoma	Membrane fusion involved in viral entry into host cell →	+1.065	+0.782	<.001	.003	3	14
BONE	Positive regulation of cell-substrate adhesion →	+0.107	+0.955	.001	<.001	3	13
BONE	Viral process →	+0.111	+1.568	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,520 associations by consensus.

Regulation of proteolysis by PTTG1IP expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →