PTTG1IP

Across TCGA cell cohorts, PTTG1IP mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTTG1IP-associated genes across cancer lineages are NEXMIF and TKTL2. Each is linked with PTTG1IP in more than 1 cancer types. Because this analysis shows association rather than direction, both PTTG1IP-to-partner and partner-to-PTTG1IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEXMIF grouped by PTTG1IP-low versus PTTG1IP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTTG1IP→partner) and Y-score (partner→PTTG1IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1
LARGE_INTESTINE	TKTL2 →	+0.064	+4.187	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

NEXMIF by PTTG1IP expression — LARGE_INTESTINE

Explore this box plot interactively →