PTTG1

Across TCGA patient cohorts, PTTG1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTTG1-associated genes across cancer lineages are Rictor_pT1135, Caspase-7-cleavedD198, and PREX1. Each is linked with PTTG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTTG1-to-partner and partner-to-PTTG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by PTTG1-low versus PTTG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTTG1→partner) and Y-score (partner→PTTG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.122	-3.169	.030	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+1.303	+3.019	<.001	.019	3	1
UCEC	PREX1 →	+0.339	+3.169	.024	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Rictor_pT1135 by PTTG1 expression — UCEC

Explore this box plot interactively →