PTTG1

Across TCGA pan-cancer cohorts, PTTG1 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of PTTG1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTTG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTTG1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where PTTG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTTG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.740	<.001	12	view →
BLCA	Male	All	+2.768	<.001	11	view →
LUAD	Male	III,IV	+2.588	<.001	11	view →
KIRP	Male	III,IV	+2.576	<.001	11	view →
KIRC	Male	IV	+2.195	<.001	11	view →
LUSC	Female	II,III,IV	+3.221	<.001	9	view →
LIHC	Female	II,III,IV	+3.098	<.001	9	view →
COAD	Female	II,III,IV	+1.468	<.001	9	view →
UCEC	All	II,III,IV	+4.060	<.001	8	view →
THCA	Male	All	−0.855	<.001	8	view →
STAD	All	II,III,IV	+2.021	<.001	7	view →
BRCA	All	III,IV	+2.783	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

PTTG1–HNSC

Open the HNSC breakdown →