PTTG1

Across TCGA cell cohorts, PTTG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,468 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTTG1-associated GO terms across cancer lineages are Positive regulation of chromosome separation, Chromosome localization, and Metaphase chromosome alignment. Each is linked with PTTG1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PTTG1-to-partner and partner-to-PTTG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome separation grouped by PTTG1-low versus PTTG1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTTG1→partner) and Y-score (partner→PTTG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of chromosome separation →	+0.186	+1.068	<.001	<.001	3	20
OVARY	Chromosome localization →	+0.102	+1.134	<.001	.001	3	19
OVARY	Metaphase chromosome alignment →	+0.110	+1.209	<.001	<.001	3	19
URINARY_TRACT	Regulation of nuclear division →	+0.135	+1.398	<.001	<.001	3	19
SOFT_TISSUE	Positive regulation of chromosome segregation →	+0.133	+0.969	<.001	<.001	3	19
OESOPHAGUS	Regulation of mitotic nuclear division →	+0.140	+1.356	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,468 associations by consensus.

Positive regulation of chromosome separation by PTTG1 expression — PANCREAS

Explore this box plot interactively →