PTS

Across TCGA patient cohorts, PTS protein abundance is significantly associated with the RNA expression of many other genes, with 6,164 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PTS-associated genes across cancer lineages are CORIN, MXRA7, and DKK3. Each is linked with PTS in more than 4 cancer types. Because this analysis shows association rather than direction, both PTS-to-partner and partner-to-PTS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTS versus CORIN in PDAC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTS→partner) and Y-score (partner→PTS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CORIN →	+0.859	+0.552	<.001	<.001	3	3
BRCA	MXRA7 →	+0.700	+0.508	<.001	.003	3	3
PDAC	DKK3 →	+0.712	+0.555	<.001	<.001	3	3
LUAD	COL11A1 →	+1.762	+0.484	<.001	.001	3	3
HNSC	SC5D →	+0.890	+0.668	<.001	<.001	3	3
HNSC	EXPH5 →	+0.672	+0.514	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,164 associations by consensus.

PTS vs CORIN — PDAC

Explore this scatter interactively →