PTRH2

Across TCGA patient cohorts, PTRH2 mutation is significantly associated with the RNA expression of many other genes, with 1,798 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTRH2-associated genes across cancer lineages are TRAJ58, MIR5692C2, and GLT6D1. Each is linked with PTRH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTRH2-to-partner and partner-to-PTRH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ58 grouped by PTRH2-low versus PTRH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTRH2→partner) and Y-score (partner→PTRH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ58 →	+0.498	+2.836	<.001	<.001	3	2
UCEC	MIR5692C2 →	+0.466	+2.525	<.001	.001	3	2
BRCA	GLT6D1 →	+0.046	+5.473	.003	.005	3	2
SKCM	TAB3P1 →	+0.100	+4.875	<.001	.002	3	2
BRCA	MIR6881 →	+1.138	+5.800	<.001	.003	3	1
UCEC	IGHV3OR16-8 →	+0.838	+3.021	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,798 associations by consensus.

TRAJ58 by PTRH2 expression — UCEC

Explore this box plot interactively →