PTRH2

Across TCGA pan-cancer cohorts, PTRH2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PTRH2 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PTRH2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTRH2 expression acts as an unfavorable survival marker, although some lineages such as LUSC and DLBC show a favorable association.

KIRP, UVM, and LIHC are the cancer types where PTRH2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.450	0.720	<.001	180	view →
UVM	DFS	Median	All	0.380	0.796	<.001	152	view →
LIHC	OS	Median	All	0.606	0.763	<.001	97	view →
ACC	DFS	Tertile	All	0.186	0.820	<.001	86	view →
SCLC	DFS	Median	III,IV	0.276	0.730	<.001	74	view →
KIRC	DFS	Quartile	II,III,IV	0.687	0.866	.008	40	view →
HNSC	DFS	Tertile	All	0.610	0.738	<.001	34	view →
KICH	DFS	Tertile	II,III,IV	0.400	1.000	.002	28	view →
SKCM	DFS	Quartile	All	0.124	0.355	.002	23	view →
LUSC	OS	Tertile	All	0.528	0.362	.006	20	view →
UCS	DFS	Tertile	IV	0.296	0.829	.024	18	view →
COAD	DFS	Quartile	IV	0.294	0.581	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PTRH2–KIRP (DFS)

Open the KIRP breakdown →