PTRH2

Across TCGA patient cohorts, PTRH2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTRH2-associated genes across cancer lineages are Notch1, JNK2, and Ku80. Each is linked with PTRH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTRH2-to-partner and partner-to-PTRH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PTRH2-low versus PTRH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTRH2→partner) and Y-score (partner→PTRH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.141	+2.584	.032	.011	3	2
UCEC	JNK2 →	+0.245	+2.584	.008	.011	3	1
UCEC	Ku80 →	+0.281	+2.598	.010	.006	3	1
UCEC	MEK1 →	+0.611	+3.584	<.001	.002	3	1
UCEC	N-Cadherin →	+0.256	+3.009	.009	.019	3	1
UCEC	Shc_pY317 →	-0.147	-3.000	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by PTRH2 expression — UCEC

Explore this box plot interactively →