PTPRZ1

Across TCGA cell cohorts, PTPRZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,840 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PTPRZ1-associated GO terms across cancer lineages are Positive regulation of cytoplasmic translation, Glial cell fate commitment, and Endodermal cell fate specification. Each is linked with PTPRZ1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPRZ1-to-partner and partner-to-PTPRZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic translation grouped by PTPRZ1-low versus PTPRZ1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRZ1→partner) and Y-score (partner→PTPRZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of cytoplasmic translation →	+0.066	+1.833	.001	.006	3	7
LUNG_NSCLC_LUSC	Glial cell fate commitment →	+1.784	+4.000	.001	<.001	3	7
LUNG_NSCLC_LUSC	Endodermal cell fate specification →	+1.741	+3.250	<.001	.001	3	6
CNS	Aerobic respiration →	+0.043	+1.036	.007	.006	3	5
LUNG_NSCLC_LUSC	Ciliary neurotrophic factor-mediated signaling pathway →	-0.197	-3.871	.002	<.001	3	5
SKIN	Negative regulation of cell maturation →	+1.171	+3.020	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,840 associations by consensus.

Positive regulation of cytoplasmic translation by PTPRZ1 expression — SKIN

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