PTPRZ1

Across TCGA pan-cancer cohorts, PTPRZ1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PTPRZ1 data layer compared with 12 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PTPRZ1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTPRZ1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

KIRP, SCLC, and BLCA are the cancer types where PTPRZ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.599	0.825	<.001	91	view →
SCLC	DFS	Quartile	II,III,IV	0.210	0.718	<.001	71	view →
BLCA	DFS	Tertile	All	0.263	0.447	.005	65	view →
HNSC	OS	Median	IV	0.809	0.649	.002	55	view →
BRCA	DFS	Median	All	0.968	0.929	.002	53	view →
UVM	DFS	Quartile	III,IV	0.203	0.910	<.001	50	view →
PAAD	OS	Tertile	All	0.653	0.406	.004	28	view →
CESC	OS	Tertile	All	0.922	0.839	.012	28	view →
THCA	DFS	Quartile	II,III,IV	0.578	0.932	.005	27	view →
MESO	DFS	Tertile	II,III,IV	0.761	0.227	.006	27	view →
THYM	DFS	Tertile	All	1.000	0.626	.006	21	view →
ACC	DFS	Tertile	III,IV	0.465	0.088	.007	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PTPRZ1–KIRP (OS)

Open the KIRP breakdown →