PTPRZ1

Across TCGA cell cohorts, PTPRZ1 mutation is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRZ1-associated genes across cancer lineages are C12orf40, OR4A47, and MREG. Each is linked with PTPRZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRZ1-to-partner and partner-to-PTPRZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by PTPRZ1-low versus PTPRZ1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRZ1→partner) and Y-score (partner→PTPRZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C12orf40 →	+0.010	+2.552	.001	.008	3	2
LUNG_NSCLC_LUSC	OR4A47 →	+0.063	+2.552	.003	.008	3	2
LUNG_NSCLC_LUAD	MREG →	+0.780	+3.378	.003	.002	3	2
LARGE_INTESTINE	E2F5 →	+0.498	+3.234	.004	.004	3	2
LARGE_INTESTINE	HPF1 →	+0.504	+1.850	.009	.006	3	2
LARGE_INTESTINE	KIF26A →	+1.041	+3.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

C12orf40 by PTPRZ1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →