PTPRZ1

Across TCGA cell cohorts, PTPRZ1 mutation is significantly associated with the mutation status of many other genes, with 4,632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRZ1-associated genes across cancer lineages are MUC4, PCDHB2, and MYH8. Each is linked with PTPRZ1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPRZ1-to-partner and partner-to-PTPRZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC4 grouped by PTPRZ1-low versus PTPRZ1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRZ1→partner) and Y-score (partner→PTPRZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MUC4 →	+2.075	+3.087	.005	.005	1	7
BLOOD_Lymphoma	PCDHB2 →	+5.554	+4.584	<.001	<.001	1	6
LUNG_SCLC	MYH8 →	+2.608	+2.608	.003	.003	1	6
KIDNEY	MAP1B →	+4.139	+4.786	.001	.001	1	6
LUNG_SCLC	DNAJC13 →	+3.023	+2.607	.006	.006	1	6
LARGE_INTESTINE	RAPGEF6 →	+4.649	+2.480	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,632 associations by consensus.

MUC4 by PTPRZ1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →