PTPRU

Across TCGA pan-cancer cohorts, PTPRU mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTPRU data layer compared with 17 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PTPRU mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPRU expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where PTPRU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.386	1.000	.002	44	view →
HNSC	DFS	Median	IV	0.945	0.593	.014	16	view →
PDAC	DFS	Tertile	All	0.688	0.889	.016	4	view →
LSCC	DFS	Tertile	All	0.645	0.887	.031	3	view →
LUAD	OS	Median	All	0.841	0.667	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PTPRU–UCEC (DFS)

Open the UCEC breakdown →