PTPRS

Across TCGA patient cohorts, PTPRS RNA expression is significantly associated with the protein abundance of many other proteins, with 20,602 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPRS-associated proteins across cancer lineages are NBEAL2, UNC13D, and NCF1_S348. Each is linked with PTPRS in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRS-to-partner and partner-to-PTPRS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPRS versus NBEAL2 in GBM, with a Pearson correlation of -0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRS→partner) and Y-score (partner→PTPRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NBEAL2 →	-0.368	-0.672	<.001	<.001	3	6
GBM	UNC13D →	-0.602	-0.851	<.001	<.001	3	6
HNSC	NCF1_S348 →	-1.044	-0.880	<.001	.001	3	5
GBM	RCOR3 →	+0.286	+0.600	<.001	<.001	3	5
UCEC	TP53BP1 →	+0.255	+0.970	.001	<.001	3	5
GBM	ZMYM2 →	+0.303	+0.758	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,602 associations by consensus.

PTPRS vs NBEAL2 — GBM

Explore this scatter interactively →