PTPRS

Across TCGA cell cohorts, PTPRS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,599 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PTPRS-associated GO terms across cancer lineages are Negative regulation of interferon-alpha production, Protein-DNA complex organization, and tRNA transcription. Each is linked with PTPRS in more than 18 cancer types. Because this analysis shows association rather than direction, both PTPRS-to-partner and partner-to-PTPRS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of interferon-alpha production grouped by PTPRS-low versus PTPRS-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRS→partner) and Y-score (partner→PTPRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of interferon-alpha production →	+2.145	+3.851	<.001	<.001	3	19
BONE	Protein-DNA complex organization →	+0.080	+1.206	<.001	<.001	3	15
BONE	tRNA transcription →	+0.149	+1.414	<.001	<.001	3	14
STOMACH	Negative regulation of DNA-templated transcription initiation →	+0.199	+2.706	<.001	.001	3	13
STOMACH	Negative regulation of transcription initiation by RNA polymerase II →	+0.199	+2.706	<.001	.001	3	13
BONE	Regulation of nucleotide-excision repair →	+0.131	+1.366	.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,599 associations by consensus.

Negative regulation of interferon-alpha production by PTPRS expression — LIVER

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