PTPRS

Across TCGA cell cohorts, PTPRS mutation is significantly associated with the RNA expression of many other genes, with 1,389 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRS-associated genes across cancer lineages are ADIPOQ, ASIC1, and NDUFAF4. Each is linked with PTPRS in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRS-to-partner and partner-to-PTPRS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by PTPRS-low versus PTPRS-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRS→partner) and Y-score (partner→PTPRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ADIPOQ →	+0.006	+3.472	<.001	.002	3	3
LARGE_INTESTINE	ASIC1 →	+0.812	+2.222	.003	.001	3	3
LARGE_INTESTINE	NDUFAF4 →	+0.492	+1.891	.002	<.001	3	3
BLOOD_Leukemia	EDEM1 →	+1.293	+3.489	<.001	.001	3	3
LARGE_INTESTINE	CNNM2 →	+0.533	+2.082	.001	.002	3	3
LARGE_INTESTINE	RNF144A →	+0.838	+1.891	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,389 associations by consensus.

ADIPOQ by PTPRS expression — BLOOD_Lymphoma

Explore this box plot interactively →