PTPRR

Across TCGA patient cohorts, PTPRR mutation is significantly associated with the RNA expression of many other genes, with 4,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRR-associated genes across cancer lineages are DDIAS, PLK1, and DDB1. Each is linked with PTPRR in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRR-to-partner and partner-to-PTPRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDIAS grouped by PTPRR-low versus PTPRR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRR→partner) and Y-score (partner→PTPRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DDIAS →	+0.633	+1.775	<.001	.003	3	4
UCEC	PLK1 →	+0.658	+1.906	<.001	<.001	3	4
SKCM	DDB1 →	+0.350	+2.156	.001	<.001	3	4
UCEC	CKAP2L →	+0.578	+1.698	<.001	<.001	3	4
SKCM	TSEN34 →	+0.334	+3.012	<.001	<.001	3	4
UCEC	MRPL36 →	+0.316	+1.960	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,832 associations by consensus.

DDIAS by PTPRR expression — SKCM

Explore this box plot interactively →