PTPRR

Across TCGA pan-cancer cohorts, PTPRR RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PTPRR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTPRR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPRR is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

HNSC, LUSC, and KIRC are the cancer types where PTPRR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.673	<.001	11	view →
LUSC	All	III,IV	−1.323	<.001	8	view →
KIRC	Female	All	+0.640	<.001	8	view →
COAD	Female	All	−1.902	<.001	6	view →
LUAD	Female	III,IV	−0.863	.002	6	view →
BRCA	All	All	+0.182	.001	6	view →
LIHC	All	All	+0.087	<.001	6	view →
READ	All	All	−1.932	<.001	5	view →
KICH	Male	II,III,IV	−0.266	.010	4	view →
BLCA	All	III,IV	+1.255	.016	3	view →
CHOL	All	All	+0.537	.011	3	view →
ESCA	All	All	+1.496	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PTPRR–HNSC

Open the HNSC breakdown →